Haemodialysis 7,500-12,500 IU (w/o preservative) per dialysis.
IV 5,000-10,000 IU every 4 hr either by bolus inj or continuous infusion in NaCl or dextrose inj.
SC 10,000 IU every 8 hr after an initial IV bolus inj of 5,000 IU.
Low-dose heparin prophylaxis 5,000 IU in 0.2 mL SC, given 2-6 hr pre-op & every 8-12 hr post-op for 10-14 days or until the patient is mobile, whichever is longer.
MI 5,000 IU SC every 12 hr beginning during the 12 hr following the 1st sign of MI.
Open heart surgery For operations <2 hr: 120 IU/kg/hr. For operations of longer duration: Administer 1½ times the dose. For each 450 mL of blood used, 2,000 IU are needed. Treatment periods vary from 10-14 days in peri-op prophylaxis to as much as 6 wk in the treatment of established thrombosis.
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